| pubmed-article:10548515 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0389003 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0205253 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C1157324 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0585064 | lld:lifeskim |
| pubmed-article:10548515 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:10548515 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10548515 | pubmed:dateCreated | 1999-12-17 | lld:pubmed |
| pubmed-article:10548515 | pubmed:abstractText | Activation of mast cells by aggregation of their high-affinity IgE receptors stimulates prostaglandin (PG) D(2) synthesis and secretion. An immediate phase of PGD(2) synthesis, complete within 30 min, is followed by a delayed, second phase of PGD(2) production that reaches a maximum 4 to 8 h after activation. Activation of mast cells from COX-2 (-/-) mice stimulates the release of PGD(2) during the first 30 min, whereas activation of mast cells from COX-1 (-/-) mice does not generate any PGD(2) in the first 2 h. On the other hand, COX-2 (-/-) cells do not participate in delayed phase of PGD(2) synthesis, while COX-1 (-/-) cells secrete low levels of PGD(2) between 2 and 4 h after activation. These data demonstrate that (i) the first phase of PG synthesis is COX-1 dependent and (ii) the second, delayed phase of PG synthesis is dependent on activation-induced synthesis and activity of COX-2. | lld:pubmed |
| pubmed-article:10548515 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10548515 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10548515 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10548515 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:10548515 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10548515 | pubmed:author | pubmed-author:HerschmanH... | lld:pubmed |
| pubmed-article:10548515 | pubmed:author | pubmed-author:LangenbachRR | lld:pubmed |
| pubmed-article:10548515 | pubmed:author | pubmed-author:MorhamS GSG | lld:pubmed |
| pubmed-article:10548515 | pubmed:author | pubmed-author:ReddyS TST | lld:pubmed |
| pubmed-article:10548515 | pubmed:author | pubmed-author:TianoH FHF | lld:pubmed |
| pubmed-article:10548515 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10548515 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10548515 | pubmed:volume | 265 | lld:pubmed |
| pubmed-article:10548515 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10548515 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10548515 | pubmed:pagination | 205-10 | lld:pubmed |
| pubmed-article:10548515 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:meshHeading | pubmed-meshheading:10548515... | lld:pubmed |
| pubmed-article:10548515 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10548515 | pubmed:articleTitle | Genetic evidence for distinct roles of COX-1 and COX-2 in the immediate and delayed phases of prostaglandin synthesis in mast cells. | lld:pubmed |
| pubmed-article:10548515 | pubmed:affiliation | Molecular Biology Institute, University of California-Los Angeles Center for the Health Sciences, Los Angeles, California, 90095, USA. | lld:pubmed |
| pubmed-article:10548515 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10548515 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10548515 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19224 | entrezgene:pubmed | pubmed-article:10548515 | lld:entrezgene |
| entrez-gene:19225 | entrezgene:pubmed | pubmed-article:10548515 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10548515 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10548515 | lld:pubmed |
