Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-9-7
pubmed:abstractText
BALB/c mice sensitized to vaccinia virus expressed G protein of respiratory syncytial virus (RSV) develop a Th2-type cytokine response and pulmonary eosinophilia when challenged with live RSV. In this study, BALB/c mice were immunized or challenged with an RSV mutant lacking the G and SH proteins or with DNA vaccines coding for RSV G or F protein. F or G protein DNA vaccines were capable of sensitizing for pulmonary eosinophilia. The absence of the G and/or SH protein in the infecting virus resulted in a consistent increase both in pulmonary natural killer cells and in gamma interferon and tumor necrosis factor expression, as well as, with primary infection, a variable increase in neutrophils and CD11b(+) cells. The development of pulmonary eosinophilia in formalin-inactivated RSV-vaccinated mice required the presence of the G and/or SH protein in the challenge virus. These data show that G and/or SH protein has a marked impact on the inflammatory and innate immune response to RSV infection.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-1591217, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-1603639, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-165119, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-3806789, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-4288226, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-4305200, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-6999535, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-7551415, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-7673713, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-7747486, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-7751644, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8035532, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8091846, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8212825, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8270885, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8345194, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8418166, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8515055, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8603960, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8662029, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8892899, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-8985399, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9200470, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9223470, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9236194, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9261421, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9391135, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9461435, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9464822, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9525607, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9557743, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9607931, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9665976, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9680139, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9725224, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9725246, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9765442, http://linkedlifedata.com/resource/pubmed/commentcorrection/10438795-9820134
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7099-107
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10438795-Animals, pubmed-meshheading:10438795-Cercopithecus aethiops, pubmed-meshheading:10438795-Cytokines, pubmed-meshheading:10438795-Disease Models, Animal, pubmed-meshheading:10438795-Female, pubmed-meshheading:10438795-HN Protein, pubmed-meshheading:10438795-Histocompatibility Antigens Class I, pubmed-meshheading:10438795-Histocompatibility Antigens Class II, pubmed-meshheading:10438795-Humans, pubmed-meshheading:10438795-Killer Cells, Natural, pubmed-meshheading:10438795-Lung Diseases, pubmed-meshheading:10438795-Mice, pubmed-meshheading:10438795-Mice, Inbred BALB C, pubmed-meshheading:10438795-Neutrophils, pubmed-meshheading:10438795-Respiratory Syncytial Virus, Human, pubmed-meshheading:10438795-Respiratory Syncytial Virus Infections, pubmed-meshheading:10438795-T-Lymphocytes, Cytotoxic, pubmed-meshheading:10438795-Th1 Cells, pubmed-meshheading:10438795-Vero Cells, pubmed-meshheading:10438795-Viral Envelope Proteins, pubmed-meshheading:10438795-Viral Proteins
pubmed:year
1999
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