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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020507,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0040300,
umls-concept:C0127082,
umls-concept:C0175677,
umls-concept:C0185117,
umls-concept:C0336867,
umls-concept:C0392756,
umls-concept:C1510800,
umls-concept:C1524063,
umls-concept:C1801960,
umls-concept:C1999216,
umls-concept:C2265920,
umls-concept:C2911684
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pubmed:issue |
24
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pubmed:dateCreated |
1999-7-8
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pubmed:abstractText |
Cell migration is a major contributor to injury-induced neointimal hyperplasia and depends on alteration of the proteolytic balance within the arterial wall toward matrix breakdown. This is partly mediated by the matrix metalloproteinases (MMPs) and their natural inhibitors, the tissue inhibitors of metalloproteinases (TIMPs).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3199-205
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10377085-Adenoviridae,
pubmed-meshheading:10377085-Angioplasty, Balloon,
pubmed-meshheading:10377085-Animals,
pubmed-meshheading:10377085-Basement Membrane,
pubmed-meshheading:10377085-Cell Division,
pubmed-meshheading:10377085-Cell Movement,
pubmed-meshheading:10377085-Cells, Cultured,
pubmed-meshheading:10377085-DNA,
pubmed-meshheading:10377085-DNA, Complementary,
pubmed-meshheading:10377085-Disease Models, Animal,
pubmed-meshheading:10377085-Extracellular Matrix,
pubmed-meshheading:10377085-Gene Expression Regulation, Viral,
pubmed-meshheading:10377085-Genetic Vectors,
pubmed-meshheading:10377085-Humans,
pubmed-meshheading:10377085-Hyperplasia,
pubmed-meshheading:10377085-Male,
pubmed-meshheading:10377085-Muscle, Smooth, Vascular,
pubmed-meshheading:10377085-Rats,
pubmed-meshheading:10377085-Rats, Wistar,
pubmed-meshheading:10377085-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:10377085-Tunica Intima
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pubmed:year |
1999
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pubmed:articleTitle |
Expression of tissue inhibitor of matrix metalloproteinases 1 by use of an adenoviral vector inhibits smooth muscle cell migration and reduces neointimal hyperplasia in the rat model of vascular balloon injury.
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pubmed:affiliation |
Hatter Institute, University College London Hospitals, the Division of Cardiovascular Genetics, Department of Medicine, University College London, London, UK. c.dollery@ucl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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