metalloendopeptidase activity

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]

metalloendopeptidase activity

EC:3.4.24, Reactome:REACT_100500 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Mus musculus", Reactome:REACT_102187 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Bos taurus", Reactome:REACT_102738 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Rattus norvegicus", Reactome:REACT_104692 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Gallus gallus", Reactome:REACT_104704 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Canis familiaris", Reactome:REACT_105137 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Taeniopygia guttata", Reactome:REACT_105311 "Pro-EGF is cleaved to form mature EGF, Rattus norvegicus", Reactome:REACT_109473 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Rattus norvegicus", Reactome:REACT_11089 "BoNT Light Chain Type E cleaves SNAP-25, Homo sapiens", Reactome:REACT_111084 "ADAM17 cleavage of Ghr, Mus musculus", Reactome:REACT_111197 "Metalloprotease cleavage of GHR, Homo sapiens", Reactome:REACT_11130 "BoNT Light Chain Type C1 cleaves SNAP-25, Homo sapiens", Reactome:REACT_11146 "BoNT Light Chain Type A cleaves SNAP-25, Homo sapiens", Reactome:REACT_11158 "BoNT Light Chain Type F cleaves VAMP, Homo sapiens", Reactome:REACT_11165 "BoNT Light Chain Type B cleaves VAMP-2, Homo sapiens", Reactome:REACT_11179 "BoNT Light Chain Type D cleaves VAMP, Homo sapiens", Reactome:REACT_11195 "BoNT Light Chain Type C1 cleaves Syntaxin, Homo sapiens", Reactome:REACT_115618 "Cleavage of P-ERBB4jmA isoforms by ADAM17, Homo sapiens", Reactome:REACT_115992 "Cleavage of P-ERBB4jmA isoforms by Adam17, Homo sapiens", Reactome:REACT_13407 "Conversion of pro-apoA-I to apoA-I, Homo sapiens", Reactome:REACT_15304 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Homo sapiens", Reactome:REACT_15447 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Homo sapiens", Reactome:REACT_15475 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Homo sapiens", Reactome:REACT_28155 "Pro-EGF is cleaved to form mature EGF, Taeniopygia guttata", Reactome:REACT_28465 "Pro-EGF is cleaved to form mature EGF, Xenopus tropicalis", Reactome:REACT_30819 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Taeniopygia guttata", Reactome:REACT_30876 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Bos taurus", Reactome:REACT_31204 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Mus musculus", Reactome:REACT_31767 "Conversion of pro-apoA-I to apoA-I, Danio rerio", Reactome:REACT_32065 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Bos taurus", Reactome:REACT_33032 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Canis familiaris", Reactome:REACT_33649 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Gallus gallus", Reactome:REACT_34637 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Danio rerio", Reactome:REACT_46117 "Pro-EGF is cleaved to form mature EGF, Gallus gallus", Reactome:REACT_48941 "Conversion of pro-apoA-I to apoA-I, Bos taurus", Reactome:REACT_79685 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Canis familiaris", Reactome:REACT_81221 "Pro-EGF is cleaved to form mature EGF, Canis familiaris", Reactome:REACT_83047 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Xenopus tropicalis", Reactome:REACT_84535 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Danio rerio", Reactome:REACT_85568 "Pro-EGF is cleaved to form mature EGF, Danio rerio", Reactome:REACT_85944 "Conversion of pro-apoA-I to apoA-I, Xenopus tropicalis", Reactome:REACT_87955 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Sus scrofa", Reactome:REACT_89938 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Xenopus tropicalis", Reactome:REACT_9030 "Mouse pro-EGF is cleaved by ADAM sheddases, Mus musculus", Reactome:REACT_90847 "Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A, Sus scrofa", Reactome:REACT_91391 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Mus musculus", Reactome:REACT_93439 "Conversion of pro-apoA-I to apoA-I, Mus musculus", Reactome:REACT_9423 "Pro-EGF is cleaved to form mature EGF, Homo sapiens", Reactome:REACT_96741 "Proteolysis of the IGF:IGFBP-3:ALS Complex by Matrix Metalloproteinase, Taeniopygia guttata", Reactome:REACT_97379 "Conversion of pro-apoA-I to apoA-I, Sus scrofa", Reactome:REACT_97836 "Conversion of pro-apoA-I to apoA-I, Canis familiaris", Reactome:REACT_98257 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Rattus norvegicus", Reactome:REACT_98581 "Proteolysis of the IGF:IGFBP-5:ALS Complex by PAPP-A2, Sus scrofa"