GENERIC endopeptidase activity

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
skos:inScheme	lld:geneontology
skos:prefLabel	endopeptidase activity
skos:altLabel	endoprotease activity
skos:notation	Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens", Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus", Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris", Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus", Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus", Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis", Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus", Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus", Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio", Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus", Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris", Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio", Reactome:REACT_105748 "APC/C:Cdh1-mediated degradation of Skp2, Canis familiaris", Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus", Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis", Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus", Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus", Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris", Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus", Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa", Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus", Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis", Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa", Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio", Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa", Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio", Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris", Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis", Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus", Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio", Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris", Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens", Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens", Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens", Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa", Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa", Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa", Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa", Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa", Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa", Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa", Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens", Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens", Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens", Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens", Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens", Reactome:REACT_1355 "Insulin degradation, Homo sapiens", Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens", Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens", Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens", Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens", Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens", Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens", Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens", Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum", Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus", Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus", Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus", Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum", Reactome:REACT_30554 "APC/C:Cdh1-mediated degradation of Skp2, Mus musculus", Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus", Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus", Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus", Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus", Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis", Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis", Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster", Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris", Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus", Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus", Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens", Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens", Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens", Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens", Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens", Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens", Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens", Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens", Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris", Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis", Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster", Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus", Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris", Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster", Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris", Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis", Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio", Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus", Reactome:REACT_79882 "APC/C:Cdh1-mediated degradation of Skp2, Rattus norvegicus", Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio", Reactome:REACT_80331 "APC/C:Cdh1-mediated degradation of Skp2, Xenopus tropicalis", Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster", Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio", Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus", Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus"

skos:definition

"Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]

skos:prefLabel

endopeptidase activity

skos:notation

Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens", Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus", Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris", Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus", Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus", Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis", Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus", Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus", Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio", Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus", Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris", Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio", Reactome:REACT_105748 "APC/C:Cdh1-mediated degradation of Skp2, Canis familiaris", Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus", Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis", Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus", Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus", Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris", Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus", Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa", Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus", Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis", Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa", Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio", Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa", Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio", Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris", Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis", Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus", Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio", Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris", Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens", Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens", Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens", Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa", Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa", Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa", Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa", Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa", Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa", Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa", Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens", Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens", Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens", Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens", Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens", Reactome:REACT_1355 "Insulin degradation, Homo sapiens", Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens", Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens", Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens", Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens", Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens", Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens", Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens", Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum", Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus", Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus", Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus", Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum", Reactome:REACT_30554 "APC/C:Cdh1-mediated degradation of Skp2, Mus musculus", Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus", Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus", Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus", Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus", Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis", Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis", Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster", Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris", Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus", Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus", Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens", Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens", Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens", Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens", Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens", Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens", Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens", Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens", Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris", Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis", Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster", Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus", Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris", Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster", Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris", Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis", Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio", Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus", Reactome:REACT_79882 "APC/C:Cdh1-mediated degradation of Skp2, Rattus norvegicus", Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio", Reactome:REACT_80331 "APC/C:Cdh1-mediated degradation of Skp2, Xenopus tropicalis", Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster", Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio", Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus", Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus"