metallopeptidase activity

"Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]

metallopeptidase activity

Reactome:REACT_100129 "Notch 4-ligand complex is cleaved to produce NEXT4, Sus scrofa", Reactome:REACT_100372 "Notch 1-ligand complex is cleaved to produce NEXT1, Gallus gallus", Reactome:REACT_100593 "Cleavage of ATF6-alpha by S2P, Drosophila melanogaster", Reactome:REACT_100677 "alpha-secretase cleaves the p75NTR extracellular domain, Rattus norvegicus", Reactome:REACT_100694 "Notch 1-ligand complex is cleaved to produce NEXT1, Xenopus tropicalis", Reactome:REACT_1011 "Notch 4-ligand complex is cleaved to produce NEXT4, Homo sapiens", Reactome:REACT_101972 "Notch 1-ligand complex is cleaved to produce NEXT1, Taeniopygia guttata", Reactome:REACT_102999 "Notch 1-ligand complex is cleaved to produce NEXT1, Drosophila melanogaster", Reactome:REACT_103085 "Cleavage of ATF6-alpha by S2P, Sus scrofa", Reactome:REACT_104327 "Notch 2-ligand complex is cleaved to produce NEXT2, Gallus gallus", Reactome:REACT_104368 "Cleavage of ATF6-alpha by S2P, Taeniopygia guttata", Reactome:REACT_107504 "alpha-secretase cleaves the p75NTR extracellular domain, Bos taurus", Reactome:REACT_109423 "Cleavage of ATF6-alpha by S2P, Bos taurus", Reactome:REACT_109532 "Notch 1-ligand complex is cleaved to produce NEXT1, Danio rerio", Reactome:REACT_114094 "Notch 3-ligand complex is cleaved to produce NEXT3, Drosophila melanogaster", Reactome:REACT_115138 "Notch 4-ligand complex is cleaved to produce NEXT4, Xenopus tropicalis", Reactome:REACT_13658 "alpha-secretase cleaves the p75NTR extracellular domain, Homo sapiens", Reactome:REACT_1552 "Notch 3-ligand complex is cleaved to produce NEXT3, Homo sapiens", Reactome:REACT_18387 "Cleavage of ATF6-alpha by S2P, Homo sapiens", Reactome:REACT_267 "Notch 2-ligand complex is cleaved to produce NEXT2, Homo sapiens", Reactome:REACT_28662 "Notch 1-ligand complex is cleaved to produce NEXT1, Bos taurus", Reactome:REACT_29018 "Notch 4-ligand complex is cleaved to produce NEXT4, Rattus norvegicus", Reactome:REACT_30292 "Notch 3-ligand complex is cleaved to produce NEXT3, Danio rerio", Reactome:REACT_30924 "Notch 2-ligand complex is cleaved to produce NEXT2, Drosophila melanogaster", Reactome:REACT_33366 "Notch 4-ligand complex is cleaved to produce NEXT4, Canis familiaris", Reactome:REACT_33539 "alpha-secretase cleaves the p75NTR extracellular domain, Gallus gallus", Reactome:REACT_33732 "Notch 4-ligand complex is cleaved to produce NEXT4, Mus musculus", Reactome:REACT_33852 "Notch 3-ligand complex is cleaved to produce NEXT3, Rattus norvegicus", Reactome:REACT_33929 "Cleavage of ATF6-alpha by S2P, Gallus gallus", Reactome:REACT_410 "Notch 1-ligand complex is cleaved to produce NEXT1, Homo sapiens", Reactome:REACT_77236 "Notch 4-ligand complex is cleaved to produce NEXT4, Bos taurus", Reactome:REACT_78816 "Notch 3-ligand complex is cleaved to produce NEXT3, Bos taurus", Reactome:REACT_79691 "alpha-secretase cleaves the p75NTR extracellular domain, Canis familiaris", Reactome:REACT_79817 "Notch 2-ligand complex is cleaved to produce NEXT2, Mus musculus", Reactome:REACT_81981 "Notch 2-ligand complex is cleaved to produce NEXT2, Bos taurus", Reactome:REACT_83198 "Notch 1-ligand complex is cleaved to produce NEXT1, Rattus norvegicus", Reactome:REACT_83310 "Notch 2-ligand complex is cleaved to produce NEXT2, Sus scrofa", Reactome:REACT_83988 "Notch 2-ligand complex is cleaved to produce NEXT2, Xenopus tropicalis", Reactome:REACT_89528 "Cleavage of ATF6-alpha by S2P, Danio rerio", Reactome:REACT_89928 "alpha-secretase cleaves the p75NTR extracellular domain, Sus scrofa", Reactome:REACT_91564 "Cleavage of ATF6-alpha by S2P, Rattus norvegicus", Reactome:REACT_92210 "alpha-secretase cleaves the p75NTR extracellular domain, Danio rerio", Reactome:REACT_92309 "Notch 3-ligand complex is cleaved to produce NEXT3, Xenopus tropicalis", Reactome:REACT_92841 "alpha-secretase cleaves the p75NTR extracellular domain, Xenopus tropicalis", Reactome:REACT_93042 "Cleavage of ATF6-alpha by S2P, Mus musculus", Reactome:REACT_94705 "Notch 2-ligand complex is cleaved to produce NEXT2, Danio rerio", Reactome:REACT_95173 "Notch 3-ligand complex is cleaved to produce NEXT3, Canis familiaris", Reactome:REACT_95565 "Notch 2-ligand complex is cleaved to produce NEXT2, Rattus norvegicus", Reactome:REACT_96136 "Notch 1-ligand complex is cleaved to produce NEXT1, Canis familiaris", Reactome:REACT_96651 "Cleavage of ATF6-alpha by S2P, Caenorhabditis elegans", Reactome:REACT_96860 "Notch 2-ligand complex is cleaved to produce NEXT2, Canis familiaris", Reactome:REACT_96983 "Cleavage of ATF6-alpha by S2P, Xenopus tropicalis", Reactome:REACT_97764 "alpha-secretase cleaves the p75NTR extracellular domain, Mus musculus", Reactome:REACT_98127 "Notch 1-ligand complex is cleaved to produce NEXT1, Mus musculus", Reactome:REACT_98562 "Cleavage of ATF6-alpha by S2P, Canis familiaris", Reactome:REACT_99318 "Notch 3-ligand complex is cleaved to produce NEXT3, Mus musculus"