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Authored: Jassal, B, 2009-02-12 10:33:32,
Edited: Jassal, B, 2009-02-12 10:33:32,
Reviewed: D'Eustachio, P, 2009-03-02 09:24:35,
Serotonin (5-HT) is a monoamine neurotransmitter that plays an important role as a modulator of anger, aggression, body temperature, mood, sleep, sexuality, appetite, metabolism, as well as stimulating vomiting. Several classes of drugs target the 5-HT system including some antidepressants, antipsychotics, anxiolytics, antiemetics and antimigraine drugs. The activity of 5-HT is modulated by 5-HT receptors, made up of seven families (5-HT1-7). All but 5-HT3 (ligand-gated ion channel) are GPCRs and these receptors bind different G proteins resulting in differing outcomes (Hoyer D et al, 1994; Kitson SL, 2007).
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Serotonin receptors
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