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Activated AMPK phosphorylates TSC2 and activates the TSC complex. TSC2 functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in conversion of Rheb-GTP into Rheb-GDP, and in inhibition of the mTOR activation by GTP-bound Rheb.,
Authored: Katajisto, P, Makela, T, Wu, J, 2008--1-1-,
Edited: Jassal, B, 2008-11-19 15:14:38,
Reviewed: Zheng, B, 2009-10-20
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Regulation of Rheb GTPase activity by AMPK
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