Source:http://www.reactome.org/biopax/48887BiochemicalReaction2978
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Authored: Katajisto, P, Makela, T, Wu, J, 2008--1-1-,
Edited: Jassal, B, 2008-11-19 15:14:38,
Reviewed: Zheng, B, 2009-10-20,
TSC2 (in the TSC complex) functions as a GTPase-activating protein and stimulates the intrinsic GTPase activity of a small G-protein Rheb. This results in the conversion of Rheb-GTP into Rheb-GDP and in the inhibition of the mTOR activation by GTP-bound Rheb (Inoki K et al, 2003; Tee AR et al, 2003).
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TSC2 activates intrinsic GTPase activity of Rheb
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