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Authored: Dall'Olio, GM, 2009-11-10,
Dolichol is a polyisoprenol lipid comprised of five-carbon isoprene units linked linearly in a head-to-tail fashion. In the N-glycan biosynthesis pathway, dolichyl phosphate is used as an anchor for the N-glycan sugar to the ER membrane, and as an initiation point for the synthesis. Dolichyl phosphate can be obtained either from direct phosphorylation of dolichol or from de-phosphorylation of dolichyl diphosphate, released at the end of the N-glycan biosynthesis pathway.,
Edited: Jassal, B, 2009-11-10,
Reviewed: Gagneux, P, 2010-04-16
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Synthesis of Dolichyl-phosphate
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