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Authored: Jassal, B, 2005-03-10 15:37:26,
Edited: Jassal, B, 2008-05-19 12:57:01,
Xenobiotics that contain either a carboxylic group or an aromatic hydroxylamine group are possible substrates for amino acid conjugation. Xenobiotics with a <i>carboxylic group</i> conjugate with an <i>amino group</i> of amino acids such as glycine, taurine and glutamine. The <i>hydroxylamine group</i> conjugates with the <i>carboxylic group</i> of amino acids such as proline and serine. The amino acid is first activated by an aminoacyl-tRNA-synthetase which then reacts with the hydroxylamine group to form a reactive N-ester. N-esters can degrade to form electrophilic nitrenium (R-N<sup>+</sup>-R') and carbonium (R-C<sup>+</sup>H<sub>2</sub>) ions. The pyrolysis product of tryptophan, an N-hydroxy intermediate, can potentially form these reactive electrophilic ions.
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Amino Acid conjugation
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