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Authored: Jassal, B, 2005-03-10 15:37:26,
Edited: Jassal, B, 2008-05-19 12:57:01,
Xenobiotics and endogenous compounds containing carboxylate groups can be activated with coenzyme A to produce acyl-CoA thioesters and then conjugated with the amino groups of glycine or glutamine to form amide-linked conjugates. Clinically important substrates include benzoic acid, phenylacetic acid, and salicylic acid.
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Conjugation of carboxylic acids
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