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Authored: Gopinathrao, G, 2005-05-12 21:32:40,
Upon dissociation of protein kinase A (PKA) tetramers in the presence of cAMP, the released PKA catalytic monomers phosphorylate specific serine and threonine residues of several metabolic enzymes. These target enzymes include glycogen phosphorylase kinase, glycogen synthase and PF2K-Pase. PKA also phosphorylates ChREBP (Carbohydrate Response Element Binding Protein), preventing its movement into the nucleus and thus its function as a positive transcription factor for genes involved in glycolytic and lipogenic reactions.
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PKA-mediated phosphorylation of key metabolic factors
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http://www.reactome.org/biopax/48887BiochemicalReaction3986,
http://www.reactome.org/biopax/48887BiochemicalReaction4707,
http://www.reactome.org/biopax/48887BiochemicalReaction4708,
http://www.reactome.org/biopax/48887BiochemicalReaction4709,
http://www.reactome.org/biopax/48887BiochemicalReaction4710
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| biopax3:pathwayOrder |