Source:http://www.reactome.org/biopax/48887BiochemicalReaction4707
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Authored: Gopinathrao, G, 2005-05-12 21:32:40,
In its active (unphosphorylated) form, ChREBP (Carbohydrate Response Element Binding Protein) binds so-called ChRE (Carbohydrate Response Element) DNA sequence motifs found upstream of several genes involved in glucose utilization and lipid synthesis, activating transcription of these genes. Phosphorylation of ChREBP at threonine residue 666 by PKA (protein kinase A) blocks this binding activity, and thus has the effect of down-regulating expression of the target genes. ChREBP phosphorylation can be reversed by the action of protein phosphatase 2A (PP2A).
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Phosphorylation of ChREBP at Thr(666) by PKA
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2.7.11.11
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