Viral protein involved in the evasion of host innate defenses by inhibiting the TBK1-IKBKE-DDX3 complex. Upon infection, the virus is recognized and the signal is transmitted to TBK1 and IKBKE that in turn phosphorylate and activate IRF3 and IRF7. Once phosphorylated, IRF3 and IRF7 homodimerize and translocate into the nucleus to drive transcription of interferons. Several viruses including Ebolavirus and Bornavirus interact directly with and inhibit TBK1 to prevent IRFs activation. Other viruses such as vaccinia virus inhibit host DDX3 to block the signaling pathway.
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| rdfs:comment |
Viral protein involved in the evasion of host innate defenses by inhibiting the TBK1-IKBKE-DDX3 complex. Upon infection, the virus is recognized and the signal is transmitted to TBK1 and IKBKE that in turn phosphorylate and activate IRF3 and IRF7. Once phosphorylated, IRF3 and IRF7 homodimerize and translocate into the nucleus to drive transcription of interferons. Several viruses including Ebolavirus and Bornavirus interact directly with and inhibit TBK1 to prevent IRFs activation. Other viruses such as vaccinia virus inhibit host DDX3 to block the signaling pathway.
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| rdfs:subClassOf | |
| rdfs:label |
Inhibition of host TBK1-IKBKE-DDX3 complex by virus
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| uniprot:category |