Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
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Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).
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1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity,
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity,
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity,
PI-PLC activity,
monophosphatidylinositol phosphodiesterase activity,
phosphatidylinositol phospholipase C activity,
phosphatidylinositol-4,5-bisphosphate hydrolysis,
phosphoinositidase C activity,
phosphoinositide phospholipase C activity,
triphosphoinositide phosphodiesterase activity
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