Source:http://linkedlifedata.com/resource/geneontology/id/GO:0097193
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP)." [GOC:mtg_apoptosis, GOC:yaf, PMID:11919192, PMID:17340152, PMID:18852119]
|
| skos:inScheme | |
| skos:prefLabel |
intrinsic apoptotic signaling pathway
|
| skos:altLabel |
intrinsic apoptotic pathway,
intrinsic apoptotic signalling pathway,
mitochondrial-mediated apoptotic pathway
|
| skos:notation |
Reactome:REACT_102619 "Intrinsic Pathway for Apoptosis, Mus musculus",
Reactome:REACT_103356 "Intrinsic Pathway for Apoptosis, Sus scrofa",
Reactome:REACT_113652 "Intrinsic Pathway for Apoptosis, Dictyostelium discoideum",
Reactome:REACT_113707 "Intrinsic Pathway for Apoptosis, Drosophila melanogaster",
Reactome:REACT_113789 "Intrinsic Pathway for Apoptosis, Oryza sativa",
Reactome:REACT_114288 "Intrinsic Pathway for Apoptosis, Arabidopsis thaliana",
Reactome:REACT_114326 "Intrinsic Pathway for Apoptosis, Schizosaccharomyces pombe",
Reactome:REACT_114572 "Intrinsic Pathway for Apoptosis, Saccharomyces cerevisiae",
Reactome:REACT_62033 "Intrinsic Pathway for Apoptosis, Canis familiaris",
Reactome:REACT_78496 "Intrinsic Pathway for Apoptosis, Rattus norvegicus",
Reactome:REACT_79211 "Intrinsic Pathway for Apoptosis, Plasmodium falciparum",
Reactome:REACT_86317 "Intrinsic Pathway for Apoptosis, Danio rerio",
Reactome:REACT_92763 "Intrinsic Pathway for Apoptosis, Gallus gallus",
Reactome:REACT_94367 "Intrinsic Pathway for Apoptosis, Xenopus tropicalis",
Reactome:REACT_96185 "Intrinsic Pathway for Apoptosis, Taeniopygia guttata",
Reactome:REACT_964 "Intrinsic Pathway for Apoptosis, Homo sapiens",
Reactome:REACT_96537 "Intrinsic Pathway for Apoptosis, Bos taurus"
|
| skos:note |
The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.).
|
| skos:broader | |
| skos:relatedSynonym |
induction of apoptosis by intracellular signals
|
| skos:narrowSynonym |
intrinsic apoptosis
|