Source:http://linkedlifedata.com/resource/geneontology/id/GO:0070371
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:add, GOC:signaling, ISBN:0121245462, ISBN:0896039986, PMID:20811974]
|
| skos:inScheme | |
| skos:prefLabel |
ERK1 and ERK2 cascade
|
| skos:altLabel |
ERK1 and ERK2 signaling pathway,
ERK1 and ERK2 signalling pathway,
ERK1/2 cascade,
extracellular signal-regulated kinase 1/2 (ERK1/2) cascade,
extracellular signal-regulated kinase 1/2 cascade
|
| skos:notation |
Reactome:REACT_100214 "ERK2 activation, Rattus norvegicus",
Reactome:REACT_102658 "ERK2 activation, Gallus gallus",
Reactome:REACT_107705 "ERK2 activation, Mus musculus",
Reactome:REACT_110773 "ERK2 activation, Danio rerio",
Reactome:REACT_111031 "ERK2 activation, Taeniopygia guttata",
Reactome:REACT_112775 "ERK2 activation, Arabidopsis thaliana",
Reactome:REACT_112819 "ERK2 activation, Dictyostelium discoideum",
Reactome:REACT_115367 "ERK2 activation, Oryza sativa",
Reactome:REACT_1183 "ERK2 activation, Homo sapiens",
Reactome:REACT_25141 "ERK2 activation, Gallus gallus",
Reactome:REACT_25393 "ERK activation, Gallus gallus",
Reactome:REACT_29696 "ERK2 activation, Saccharomyces cerevisiae",
Reactome:REACT_77794 "ERK2 activation, Xenopus tropicalis",
Reactome:REACT_77829 "ERK2 activation, Bos taurus",
Reactome:REACT_81711 "ERK2 activation, Drosophila melanogaster",
Reactome:REACT_90463 "ERK2 activation, Caenorhabditis elegans",
Reactome:REACT_94688 "ERK2 activation, Sus scrofa",
Reactome:REACT_97178 "ERK2 activation, Schizosaccharomyces pombe",
Reactome:REACT_97662 "ERK2 activation, Canis familiaris"
|
| skos:note |
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
|
| skos:broader | |
| skos:narrowSynonym |
ERK1 cascade,
ERK2 cascade,
MAPK1 cascade,
MAPK3 cascade
|
| skos:broadSynonym |
ERK cascade
|