Source:http://linkedlifedata.com/resource/geneontology/id/GO:0000165
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267]
|
| skos:inScheme | |
| skos:prefLabel |
MAPK cascade
|
| skos:altLabel |
MAP kinase cascade,
MAP kinase kinase kinase cascade,
MAPKKK cascade,
mitogen-activated protein kinase cascade
|
| skos:notation |
Reactome:REACT_101634 "RAF/MAP kinase cascade, Bos taurus",
Reactome:REACT_107261 "RAF/MAP kinase cascade, Saccharomyces cerevisiae",
Reactome:REACT_107863 "RAF/MAP kinase cascade, Canis familiaris",
Reactome:REACT_108330 "RAF/MAP kinase cascade, Xenopus tropicalis",
Reactome:REACT_112235 "RAF/MAP kinase cascade, Dictyostelium discoideum",
Reactome:REACT_112942 "RAF/MAP kinase cascade, Arabidopsis thaliana",
Reactome:REACT_113285 "RAF/MAP kinase cascade, Oryza sativa",
Reactome:REACT_634 "RAF/MAP kinase cascade, Homo sapiens",
Reactome:REACT_79658 "RAF/MAP kinase cascade, Schizosaccharomyces pombe",
Reactome:REACT_85806 "RAF/MAP kinase cascade, Drosophila melanogaster",
Reactome:REACT_87028 "RAF/MAP kinase cascade, Danio rerio",
Reactome:REACT_87232 "RAF/MAP kinase cascade, Mus musculus",
Reactome:REACT_87855 "RAF/MAP kinase cascade, Rattus norvegicus",
Reactome:REACT_92078 "RAF/MAP kinase cascade, Sus scrofa",
Reactome:REACT_92987 "RAF/MAP kinase cascade, Caenorhabditis elegans",
Reactome:REACT_94585 "RAF/MAP kinase cascade, Taeniopygia guttata",
Reactome:REACT_94805 "RAF/MAP kinase cascade, Gallus gallus",
Wikipedia:MAPK_cascade,
Wikipedia:Mitogen-activated_protein_kinase
|
| skos:note |
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
|
| skos:broader | |
| skos:relatedSynonym |
MAPK signaling,
MAPK signalling
|
| skos:narrowSynonym |
ERK/MAPK cascade,
MAPKKK cascade during sporulation
|