Source:http://linkedlifedata.com/resource/geneontology/id/GO:0043224
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]
|
| skos:inScheme | |
| skos:prefLabel |
nuclear SCF ubiquitin ligase complex
|
| skos:altLabel |
nuclear SCF complex,
nuclear Skp1/Cul1/F-box protein complex,
nuclear cullin complex
|
| skos:broader |