Source:http://linkedlifedata.com/resource/geneontology/id/GO:0008534
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296]
|
| skos:inScheme | |
| skos:prefLabel |
oxidized purine nucleobase lesion DNA N-glycosylase activity
|
| skos:altLabel |
2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity,
2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity,
DNA-formamidopyrimidine glycosylase activity,
Fapy-DNA glycosylase activity,
deoxyribonucleate glycosidase activity,
formamidopyrimidine-DNA glycosylase activity,
oxidized purine base lesion DNA N-glycosylase activity
|
| skos:notation |
EC:3.2.2.23,
MetaCyc:3.2.2.23-RXN,
Reactome:REACT_1013 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Homo sapiens",
Reactome:REACT_105365 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Dictyostelium discoideum",
Reactome:REACT_106495 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Danio rerio",
Reactome:REACT_106926 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Mus musculus",
Reactome:REACT_1737 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Homo sapiens",
Reactome:REACT_28313 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Rattus norvegicus",
Reactome:REACT_28730 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Saccharomyces cerevisiae",
Reactome:REACT_28897 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Gallus gallus",
Reactome:REACT_30986 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Gallus gallus",
Reactome:REACT_34247 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Arabidopsis thaliana",
Reactome:REACT_78313 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Dictyostelium discoideum",
Reactome:REACT_78507 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Drosophila melanogaster",
Reactome:REACT_80636 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Arabidopsis thaliana",
Reactome:REACT_81413 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Plasmodium falciparum",
Reactome:REACT_83644 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Mus musculus",
Reactome:REACT_83822 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Sus scrofa",
Reactome:REACT_85747 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Drosophila melanogaster",
Reactome:REACT_88552 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Saccharomyces cerevisiae",
Reactome:REACT_90260 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Bos taurus",
Reactome:REACT_91493 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Sus scrofa",
Reactome:REACT_92331 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Rattus norvegicus",
Reactome:REACT_93857 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Canis familiaris",
Reactome:REACT_95950 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Danio rerio",
Reactome:REACT_97968 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Plasmodium falciparum",
Reactome:REACT_98820 "Cleavage of 8-oxo guanine by hOGG1 glycosylase, Canis familiaris",
Reactome:REACT_98984 "Cleavage of formamidopyrimidine by hOGG1 glycosylase, Bos taurus"
|
| skos:note |
Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
|
| skos:broader | |
| skos:relatedSynonym |
DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing],
Fpg protein,
purine-specific oxidized base lesion DNA N-glycosylase activity
|
| skos:broadSynonym |
8-oxoguanine DNA glycosylase activity,
bifunctional DNA glycosylase activity,
DNA glycosylase/AP-lyase activity,
DNA glycosylase/beta-lyase activity
|