GENERIC MyD88-independent toll-like receptor signaling pathway

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	skos:Concept
skos:definition	"Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]
skos:inScheme	lld:geneontology
skos:prefLabel	MyD88-independent toll-like receptor signaling pathway
skos:altLabel	MyD88-independent TLR signaling pathway, MyD88-independent toll-like receptor signalling pathway
skos:notation	Reactome:REACT_100200 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Gallus gallus", Reactome:REACT_102299 "MyD88-independent cascade initiated on plasma membrane, Caenorhabditis elegans", Reactome:REACT_102509 "TRAF6 Mediated Induction of proinflammatory cytokines, Dictyostelium discoideum", Reactome:REACT_102886 "TRAF6 Mediated Induction of proinflammatory cytokines, Saccharomyces cerevisiae", Reactome:REACT_104655 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Mus musculus", Reactome:REACT_105840 "TRAF6 Mediated Induction of proinflammatory cytokines, Gallus gallus", Reactome:REACT_105924 "TRAF6 Mediated Induction of proinflammatory cytokines, Mus musculus", Reactome:REACT_106037 "TRAF6 Mediated Induction of proinflammatory cytokines, Canis familiaris", Reactome:REACT_106039 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Mus musculus", Reactome:REACT_106964 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Danio rerio", Reactome:REACT_109458 "TRAF6 Mediated Induction of proinflammatory cytokines, Rattus norvegicus", Reactome:REACT_110829 "MyD88-independent cascade initiated on plasma membrane, Canis familiaris", Reactome:REACT_110980 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Danio rerio", Reactome:REACT_114143 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Drosophila melanogaster", Reactome:REACT_25148 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Homo sapiens", Reactome:REACT_28259 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Xenopus tropicalis", Reactome:REACT_28395 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Bos taurus", Reactome:REACT_28410 "MyD88-independent cascade initiated on plasma membrane, Oryza sativa", Reactome:REACT_28525 "MyD88-independent cascade initiated on plasma membrane, Schizosaccharomyces pombe", Reactome:REACT_29826 "MyD88-independent cascade initiated on plasma membrane, Gallus gallus", Reactome:REACT_30390 "TRAF6 Mediated Induction of proinflammatory cytokines, Arabidopsis thaliana", Reactome:REACT_31920 "TRAF6 Mediated Induction of proinflammatory cytokines, Sus scrofa", Reactome:REACT_32587 "MyD88-independent cascade initiated on plasma membrane, Mus musculus", Reactome:REACT_32888 "MyD88-independent cascade initiated on plasma membrane, Sus scrofa", Reactome:REACT_33115 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Taeniopygia guttata", Reactome:REACT_33276 "MyD88-independent cascade initiated on plasma membrane, Danio rerio", Reactome:REACT_33454 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Sus scrofa", Reactome:REACT_33857 "TRAF6 Mediated Induction of proinflammatory cytokines, Oryza sativa", Reactome:REACT_34578 "TRAF6 Mediated Induction of proinflammatory cytokines, Drosophila melanogaster", Reactome:REACT_6782 "TRAF6 Mediated Induction of proinflammatory cytokines, Homo sapiens", Reactome:REACT_6809 "MyD88-independent cascade initiated on plasma membrane, Homo sapiens", Reactome:REACT_6898 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Homo sapiens", Reactome:REACT_6976 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Homo sapiens", Reactome:REACT_70758 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Gallus gallus", Reactome:REACT_78892 "MyD88-independent cascade initiated on plasma membrane, Saccharomyces cerevisiae", Reactome:REACT_79777 "TRAF6 Mediated Induction of proinflammatory cytokines, Caenorhabditis elegans", Reactome:REACT_81045 "TRAF6 Mediated Induction of proinflammatory cytokines, Danio rerio", Reactome:REACT_81308 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Bos taurus", Reactome:REACT_81312 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Sus scrofa", Reactome:REACT_82068 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Rattus norvegicus", Reactome:REACT_83083 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Canis familiaris", Reactome:REACT_85389 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Rattus norvegicus", Reactome:REACT_85560 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Rattus norvegicus", Reactome:REACT_85813 "MyD88-independent cascade initiated on plasma membrane, Arabidopsis thaliana", Reactome:REACT_87120 "MyD88-independent cascade initiated on plasma membrane, Dictyostelium discoideum", Reactome:REACT_88311 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Xenopus tropicalis", Reactome:REACT_88396 "MyD88-independent cascade initiated on plasma membrane, Xenopus tropicalis", Reactome:REACT_88627 "TRAF6 Mediated Induction of proinflammatory cytokines, Schizosaccharomyces pombe", Reactome:REACT_89370 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Xenopus tropicalis", Reactome:REACT_89942 "MyD88-independent cascade initiated on plasma membrane, Rattus norvegicus", Reactome:REACT_90312 "TRAF6 Mediated Induction of proinflammatory cytokines, Bos taurus", Reactome:REACT_91487 "TRAF6 Mediated Induction of proinflammatory cytokines, Xenopus tropicalis", Reactome:REACT_91606 "MyD88-independent cascade initiated on plasma membrane, Taeniopygia guttata", Reactome:REACT_92796 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Taeniopygia guttata", Reactome:REACT_93657 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Canis familiaris", Reactome:REACT_94894 "TRAF6 Mediated Induction of proinflammatory cytokines, Taeniopygia guttata", Reactome:REACT_95971 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Taeniopygia guttata", Reactome:REACT_96392 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Bos taurus", Reactome:REACT_96482 "MyD88-independent cascade initiated on plasma membrane, Bos taurus", Reactome:REACT_97209 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Gallus gallus", Reactome:REACT_98583 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Sus scrofa", Reactome:REACT_99022 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Danio rerio", Reactome:REACT_99202 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Canis familiaris", Reactome:REACT_99347 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Mus musculus", Reactome:REACT_99643 "MyD88-independent cascade initiated on plasma membrane, Drosophila melanogaster"
skos:broader	http://linkedlifedata.com/resource/geneontology/id/GO:0002224

skos:definition

"Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]

skos:prefLabel

MyD88-independent toll-like receptor signaling pathway

skos:notation

Reactome:REACT_100200 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Gallus gallus", Reactome:REACT_102299 "MyD88-independent cascade initiated on plasma membrane, Caenorhabditis elegans", Reactome:REACT_102509 "TRAF6 Mediated Induction of proinflammatory cytokines, Dictyostelium discoideum", Reactome:REACT_102886 "TRAF6 Mediated Induction of proinflammatory cytokines, Saccharomyces cerevisiae", Reactome:REACT_104655 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Mus musculus", Reactome:REACT_105840 "TRAF6 Mediated Induction of proinflammatory cytokines, Gallus gallus", Reactome:REACT_105924 "TRAF6 Mediated Induction of proinflammatory cytokines, Mus musculus", Reactome:REACT_106037 "TRAF6 Mediated Induction of proinflammatory cytokines, Canis familiaris", Reactome:REACT_106039 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Mus musculus", Reactome:REACT_106964 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Danio rerio", Reactome:REACT_109458 "TRAF6 Mediated Induction of proinflammatory cytokines, Rattus norvegicus", Reactome:REACT_110829 "MyD88-independent cascade initiated on plasma membrane, Canis familiaris", Reactome:REACT_110980 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Danio rerio", Reactome:REACT_114143 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Drosophila melanogaster", Reactome:REACT_25148 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Homo sapiens", Reactome:REACT_28259 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Xenopus tropicalis", Reactome:REACT_28395 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Bos taurus", Reactome:REACT_28410 "MyD88-independent cascade initiated on plasma membrane, Oryza sativa", Reactome:REACT_28525 "MyD88-independent cascade initiated on plasma membrane, Schizosaccharomyces pombe", Reactome:REACT_29826 "MyD88-independent cascade initiated on plasma membrane, Gallus gallus", Reactome:REACT_30390 "TRAF6 Mediated Induction of proinflammatory cytokines, Arabidopsis thaliana", Reactome:REACT_31920 "TRAF6 Mediated Induction of proinflammatory cytokines, Sus scrofa", Reactome:REACT_32587 "MyD88-independent cascade initiated on plasma membrane, Mus musculus", Reactome:REACT_32888 "MyD88-independent cascade initiated on plasma membrane, Sus scrofa", Reactome:REACT_33115 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Taeniopygia guttata", Reactome:REACT_33276 "MyD88-independent cascade initiated on plasma membrane, Danio rerio", Reactome:REACT_33454 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Sus scrofa", Reactome:REACT_33857 "TRAF6 Mediated Induction of proinflammatory cytokines, Oryza sativa", Reactome:REACT_34578 "TRAF6 Mediated Induction of proinflammatory cytokines, Drosophila melanogaster", Reactome:REACT_6782 "TRAF6 Mediated Induction of proinflammatory cytokines, Homo sapiens", Reactome:REACT_6809 "MyD88-independent cascade initiated on plasma membrane, Homo sapiens", Reactome:REACT_6898 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Homo sapiens", Reactome:REACT_6976 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Homo sapiens", Reactome:REACT_70758 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Gallus gallus", Reactome:REACT_78892 "MyD88-independent cascade initiated on plasma membrane, Saccharomyces cerevisiae", Reactome:REACT_79777 "TRAF6 Mediated Induction of proinflammatory cytokines, Caenorhabditis elegans", Reactome:REACT_81045 "TRAF6 Mediated Induction of proinflammatory cytokines, Danio rerio", Reactome:REACT_81308 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Bos taurus", Reactome:REACT_81312 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Sus scrofa", Reactome:REACT_82068 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Rattus norvegicus", Reactome:REACT_83083 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Canis familiaris", Reactome:REACT_85389 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Rattus norvegicus", Reactome:REACT_85560 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Rattus norvegicus", Reactome:REACT_85813 "MyD88-independent cascade initiated on plasma membrane, Arabidopsis thaliana", Reactome:REACT_87120 "MyD88-independent cascade initiated on plasma membrane, Dictyostelium discoideum", Reactome:REACT_88311 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Xenopus tropicalis", Reactome:REACT_88396 "MyD88-independent cascade initiated on plasma membrane, Xenopus tropicalis", Reactome:REACT_88627 "TRAF6 Mediated Induction of proinflammatory cytokines, Schizosaccharomyces pombe", Reactome:REACT_89370 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Xenopus tropicalis", Reactome:REACT_89942 "MyD88-independent cascade initiated on plasma membrane, Rattus norvegicus", Reactome:REACT_90312 "TRAF6 Mediated Induction of proinflammatory cytokines, Bos taurus", Reactome:REACT_91487 "TRAF6 Mediated Induction of proinflammatory cytokines, Xenopus tropicalis", Reactome:REACT_91606 "MyD88-independent cascade initiated on plasma membrane, Taeniopygia guttata", Reactome:REACT_92796 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Taeniopygia guttata", Reactome:REACT_93657 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Canis familiaris", Reactome:REACT_94894 "TRAF6 Mediated Induction of proinflammatory cytokines, Taeniopygia guttata", Reactome:REACT_95971 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Taeniopygia guttata", Reactome:REACT_96392 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Bos taurus", Reactome:REACT_96482 "MyD88-independent cascade initiated on plasma membrane, Bos taurus", Reactome:REACT_97209 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Gallus gallus", Reactome:REACT_98583 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Sus scrofa", Reactome:REACT_99022 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1, Danio rerio", Reactome:REACT_99202 "Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, Canis familiaris", Reactome:REACT_99347 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon, Mus musculus", Reactome:REACT_99643 "MyD88-independent cascade initiated on plasma membrane, Drosophila melanogaster"