Source:http://linkedlifedata.com/resource/umls/id/C0164005
MSH: A thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN.,NCI: The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. The expression of these enzymes is tissue-specific and developmentally regulated. Members of this deubiquitinating family are also important modulators of cellular function. (NCI)