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skos:definition |
NCI: AXL protein is a transmembrane receptor tyrosine kinase with novel structure, is evolutionarily conserved among vertebrate species, and is widely expressed in monocytes and macrophages but not in B- or T-lymphocytes. The transforming capacity of AXL results from over expression, rather than from structural mutation. Although normal AXL function is unknown, the transforming activity of AXL demonstrates that the receptor can drive cell proliferation. Growth arrest-specific gene-6 is an AXL stimulatory factor. (from OMIM 109135 and NCI)
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