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skos:definition |
MSH: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.,CSP: agents that suppress immune function by one of several mechanisms of action; cytotoxic immunosuppressants act by inhibiting DNA synthesis; others may act through activation of suppressor T-cell populations or by inhibiting the activation of helper cells.,NCI: An agent that decreases the body's immune responses. It reduces the body's ability to fight infections and other diseases, such as cancer. Immunosuppressants may be used to keep a person from rejecting a bone marrow or organ transplant. They are also used in the treatment of conditions marked b
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