Source:http://linkedlifedata.com/resource/umls/id/C0060483
PDQ: The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39244&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39244&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1094" NCI Thesaurus),CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,NCI: A drug used to treat B-cell chronic lymphocytic leukemia (CLL) that has not responded to treatment with other anti