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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-3-18
|
| pubmed:abstractText |
Numerous studies suggest that supplemental vitamin E prior to or during vast surgeries might diminish or even prevent ischemia/reperfusion-induced injuries. In the present placebo-controlled study male Sprague-Dawley rats were supplemented parenterally or orally with alpha-tocopherol for three consecutive days. The applied amount of alpha-tocopherol was 2.3 micromol per day for oral and 1.2 micromol per day for parenteral supplementation. The enrichment of vitamin E concentrations in plasma and tissue samples (aortic endothelium, liver, and lung) was determined by HPLC. The vitamin E level was elevated following intravenous supplementation in plasma (21.4 +/- 1.9 micromol/L vs. 10.2 +/- 1.7 micromol/L in parenteral control group), in aortic endothelium (1.1 +/- 0.2 pmol/mm2 vs. 0.5 +/- 0.1 pmol/mm2) and in liver and lung (41.3 +/- 7.5 pmol/mg vs. 22.9 +/- 6.5 pmol/mg and 75.6 +/- 13.6 pmol/mg vs. 51.7 +/- 5.9 pmol/mg, respectively). Oral supplementation for three days also led to an increased level in liver (38.2 +/- 7.7 pmol/mg vs. 22.9 +/- 6.6 pmol/mg in oral control group) and in lung (67.8 +/- 5.7 pmol/mg vs. 51.7 +/- 9.3 pmol/mg) but not in aortic endothelium or plasma (0.8 +/- 0.3 pmol/mm2 vs. 0.6 +/- 0.3 pmol/mm2 and 12.0 +/- 2.2 micromol/L vs. 10.7 +/- 2.6 micromol/L).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1071-5762
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9925034-Administration, Oral,
pubmed-meshheading:9925034-Animals,
pubmed-meshheading:9925034-Aorta,
pubmed-meshheading:9925034-Endothelium, Vascular,
pubmed-meshheading:9925034-Liver,
pubmed-meshheading:9925034-Lung,
pubmed-meshheading:9925034-Male,
pubmed-meshheading:9925034-Parenteral Nutrition,
pubmed-meshheading:9925034-Placebos,
pubmed-meshheading:9925034-Rats,
pubmed-meshheading:9925034-Rats, Sprague-Dawley,
pubmed-meshheading:9925034-Vitamin E
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Short-term parenteral application of alpha-tocopherol leads to increased concentration in plasma and tissues of the rat.
|
| pubmed:affiliation |
Department of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|