Linked Life Data

9838066

Source:http://linkedlifedata.com/resource/pubmed/id/9838066

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1999-2-1
pubmed:abstractText
Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. VCM may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferases (GSTs). Thus workers with inherited variant metabolic enzyme activities may have an altered risk of genotoxicity. This study was designed to investigate which risk factors might affect sister chromatid exchange (SCE) frequency in polyvinyl chloride (PVC) workers. Study subjects were 44 male workers from three PVC factories. Questionnaires were administered to obtain detailed histories of cigarette smoking, alcohol consumption, occupations, and medications. SCE frequency in peripheral lymphocytes was determined using a standardized method, and CYP2E1, GSTM1, GSTT1 and ALDH2 genotypes were identified by the polymerase chain reaction (PCR). Analysis revealed that smoking status and exposure to VCM were significantly associated with increased SCE frequency. The presence of ALDH2 1-2/2-2 genotypes was also significantly associated with an elevation of SCE frequency (9. 5 vs. 8.1, p<0.01). However, CYP2E1, GSTM1 or GSTT1 genotypes were not significantly associated with SCE frequency. When various genotypes were considered together, combination of CYP2E1 c1c2/c2c2 with ALDH2 1-2/2-2 showed an additive effect on SCE frequency. Similar results were also found for the combination of smoking with CYP2E1, or smoking with ALDH2. These results suggest that VCM workers with ALDH2 1-2/2-2 genotypes, who also smoke, may have increased risk of DNA damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-5107
pubmed:author
pubmed:copyrightInfo
Copyright 1998 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
420
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-107
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9838066-Adult, pubmed-meshheading:9838066-Aldehyde Dehydrogenase, pubmed-meshheading:9838066-Carcinogens, pubmed-meshheading:9838066-Cytochrome P-450 Enzyme System, pubmed-meshheading:9838066-DNA Damage, pubmed-meshheading:9838066-DNA Primers, pubmed-meshheading:9838066-Drinking Behavior, pubmed-meshheading:9838066-Glutathione Transferase, pubmed-meshheading:9838066-Humans, pubmed-meshheading:9838066-Least-Squares Analysis, pubmed-meshheading:9838066-Male, pubmed-meshheading:9838066-Middle Aged, pubmed-meshheading:9838066-Occupational Exposure, pubmed-meshheading:9838066-Polymerase Chain Reaction, pubmed-meshheading:9838066-Polymorphism, Restriction Fragment Length, pubmed-meshheading:9838066-Polyvinyl Chloride, pubmed-meshheading:9838066-Questionnaires, pubmed-meshheading:9838066-Risk Factors, pubmed-meshheading:9838066-Sister Chromatid Exchange, pubmed-meshheading:9838066-Smoking, pubmed-meshheading:9838066-Vinyl Chloride
pubmed:year
1998
pubmed:articleTitle
Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers.
pubmed:affiliation
Graduate Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University, College of Public Health, Taipei, Taiwan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't