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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1998-12-29
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pubmed:abstractText |
The distribution of TmDOTP5- in rat tissue was compared with CoEDTA-, an anionic complex previously used as a marker of extracellular space. Heart, liver, muscle, blood, and urine were collected from rats after infusion of either complex and were quantitatively analyzed by atomic absorption spectroscopy. Although total TmDOTP5- in blood and tissue was consistently lower (0.88 +/- 0.04; n = 6) than CoEDTA- after an identical infusion protocol (presumably because of some association of the phosphonate complex with bone), a comparison of blood and tissue contents indicated that the two anionic complexes distributed into identical extracellular spaces. Relative extracellular space in the in vivo liver, as determined by TmDOTP5- and CoEDTA-, was 0.18 +/- 0.02 and 0.15 +/- 0.01, respectively. The corresponding relative extracellular space values for the in vivo heart reported by the two agents were identical (0. 11 +/- 0.02). Experiments were also performed to evaluate the washout kinetics of TmDOTP5- from anesthesized rats. In rats given a total dose of 0.16 mmol TmDOTP5-, 81% appeared in urine by 180 min, <2% was found in all remaining soft tissue, leaving approximately 18% undetected. The rate of Tm appearance in urine was fit to a standard pharmacokinetic model that included four tissue compartments: plasma, one fast equilbrating space, one slow equilibrating space, and one very slow equilibrating space (presumably bone). The best fit result suggests that the highly charged TmDOTP5- complex is cleared from plasma more rapidly than is the typical lower charged Gd-based contrast agents and that release from bone is slow compared with renal clearance.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Edetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Magnesium,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Thulium,
http://linkedlifedata.com/resource/pubmed/chemical/thulium(III)...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
8750-7587
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1800-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9804584-Animals,
pubmed-meshheading:9804584-Calcium,
pubmed-meshheading:9804584-Chelating Agents,
pubmed-meshheading:9804584-Edetic Acid,
pubmed-meshheading:9804584-Extracellular Space,
pubmed-meshheading:9804584-Liver,
pubmed-meshheading:9804584-Magnesium,
pubmed-meshheading:9804584-Male,
pubmed-meshheading:9804584-Models, Biological,
pubmed-meshheading:9804584-Myocardium,
pubmed-meshheading:9804584-Organometallic Compounds,
pubmed-meshheading:9804584-Organophosphorus Compounds,
pubmed-meshheading:9804584-Rats,
pubmed-meshheading:9804584-Rats, Sprague-Dawley,
pubmed-meshheading:9804584-Spectrophotometry, Atomic,
pubmed-meshheading:9804584-Thulium,
pubmed-meshheading:9804584-Tissue Distribution
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pubmed:year |
1998
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pubmed:articleTitle |
Distribution of TmDOTP5- in rat tissues: TmDOTP5- vs. CoEDTA- as markers of extracellular tissue space.
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pubmed:affiliation |
Department of Chemistry, University of Texas at Dallas, Richardson, 75083-0688, Texas, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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