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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1998-11-23
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pubmed:abstractText |
The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-alpha and IFN-gamma. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-gamma and TNF-alpha anticancerous action.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Laminin,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
251
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
564-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9792813-Cell Line, Transformed,
pubmed-meshheading:9792813-Gene Expression Regulation,
pubmed-meshheading:9792813-HeLa Cells,
pubmed-meshheading:9792813-Humans,
pubmed-meshheading:9792813-Interferon-gamma,
pubmed-meshheading:9792813-Keratinocytes,
pubmed-meshheading:9792813-Luciferases,
pubmed-meshheading:9792813-Neoplasm Metastasis,
pubmed-meshheading:9792813-Promoter Regions, Genetic,
pubmed-meshheading:9792813-Protein Biosynthesis,
pubmed-meshheading:9792813-Protein Precursors,
pubmed-meshheading:9792813-RNA, Messenger,
pubmed-meshheading:9792813-Receptors, Laminin,
pubmed-meshheading:9792813-Recombinant Fusion Proteins,
pubmed-meshheading:9792813-Recombinant Proteins,
pubmed-meshheading:9792813-Ribosomal Proteins,
pubmed-meshheading:9792813-Transcription, Genetic,
pubmed-meshheading:9792813-Transfection,
pubmed-meshheading:9792813-Tumor Necrosis Factor-alpha
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pubmed:year |
1998
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pubmed:articleTitle |
TNF-alpha and IFN-gamma down-regulate the expression of the metastasis-associated bi-functional 37LRP/p40 gene and protein in transformed keratinocytes.
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pubmed:affiliation |
Metastasis Research Laboratory, Sart Tilman, Liège, B-4000, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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