rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
1998-11-5
|
pubmed:abstractText |
Tumor necrosis factor (TNF)-alpha appears central to the pathogenesis of severe sepsis, but aspects of the cytokine cascade and the link to physiologic responses are poorly defined. We hypothesized that a monoclonal antibody to TNF-alpha given early in the course of severe sepsis would modify the pattern of systemic cytokine release and, as a consequence, resuscitation fluid requirements, net proteolysis, and hypermetabolism would be reduced.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0090-3493
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
26
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1650-9
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9781721-Adult,
pubmed-meshheading:9781721-Aged,
pubmed-meshheading:9781721-Antibodies, Monoclonal,
pubmed-meshheading:9781721-Body Composition,
pubmed-meshheading:9781721-Body Water,
pubmed-meshheading:9781721-Double-Blind Method,
pubmed-meshheading:9781721-Energy Metabolism,
pubmed-meshheading:9781721-Female,
pubmed-meshheading:9781721-Hemodynamics,
pubmed-meshheading:9781721-Humans,
pubmed-meshheading:9781721-Interleukins,
pubmed-meshheading:9781721-Male,
pubmed-meshheading:9781721-Middle Aged,
pubmed-meshheading:9781721-Sepsis,
pubmed-meshheading:9781721-Survival Analysis,
pubmed-meshheading:9781721-Time Factors,
pubmed-meshheading:9781721-Tumor Necrosis Factor-alpha
|
pubmed:year |
1998
|
pubmed:articleTitle |
Effect of a chimeric antibody to tumor necrosis factor-alpha on cytokine and physiologic responses in patients with severe sepsis--a randomized, clinical trial.
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pubmed:affiliation |
University Department of Surgery, Auckland Hospital, New Zealand.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|