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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5383
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pubmed:dateCreated |
1998-10-7
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pubmed:databankReference |
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pubmed:abstractText |
The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/hematopoietic progenitor kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/mitogen-activated protein kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/mitogen-activated protein kinase...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1671-4
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:9733513-Animals,
pubmed-meshheading:9733513-COS Cells,
pubmed-meshheading:9733513-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9733513-Carrier Proteins,
pubmed-meshheading:9733513-Cell Line,
pubmed-meshheading:9733513-Cercopithecus aethiops,
pubmed-meshheading:9733513-Enzyme Activation,
pubmed-meshheading:9733513-Interleukin-1,
pubmed-meshheading:9733513-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:9733513-MAP Kinase Kinase 7,
pubmed-meshheading:9733513-MAP Kinase Kinase Kinases,
pubmed-meshheading:9733513-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:9733513-Mitogen-Activated Protein Kinases,
pubmed-meshheading:9733513-Molecular Sequence Data,
pubmed-meshheading:9733513-Protein Kinases,
pubmed-meshheading:9733513-Protein-Serine-Threonine Kinases,
pubmed-meshheading:9733513-Recombinant Fusion Proteins,
pubmed-meshheading:9733513-Signal Transduction
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pubmed:year |
1998
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pubmed:articleTitle |
A mammalian scaffold complex that selectively mediates MAP kinase activation.
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pubmed:affiliation |
Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School and Howard Hughes Medical Institute, Worcester, MA 01605, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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