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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5375
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pubmed:dateCreated |
1998-8-13
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pubmed:abstractText |
Cell interactions mediated by Notch-family receptors have been implicated in the specification of tissue boundaries in vertebrate and insect development. Although Notch ligands are often widely expressed, tightly localized activation of Notch is critical for the formation of sharp boundaries. Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral boundary in the Drosophila wing. Nubbin represses Notch-dependent target genes and sets a threshold for Notch activity that defines the spatial domain of boundary-specific gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Acetylglucosaminyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/POU Domain Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Serrate proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/delta protein,
http://linkedlifedata.com/resource/pubmed/chemical/fng protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/nubbin protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/vestigial protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
281
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
409-13
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9665883-Animals,
pubmed-meshheading:9665883-Calcium-Binding Proteins,
pubmed-meshheading:9665883-Drosophila,
pubmed-meshheading:9665883-Drosophila Proteins,
pubmed-meshheading:9665883-Enhancer Elements, Genetic,
pubmed-meshheading:9665883-Gene Expression Regulation,
pubmed-meshheading:9665883-Genes, Insect,
pubmed-meshheading:9665883-Homeodomain Proteins,
pubmed-meshheading:9665883-Insect Proteins,
pubmed-meshheading:9665883-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:9665883-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:9665883-Ligands,
pubmed-meshheading:9665883-Membrane Proteins,
pubmed-meshheading:9665883-Mutation,
pubmed-meshheading:9665883-N-Acetylglucosaminyltransferases,
pubmed-meshheading:9665883-Nuclear Proteins,
pubmed-meshheading:9665883-POU Domain Factors,
pubmed-meshheading:9665883-Proto-Oncogene Proteins,
pubmed-meshheading:9665883-Receptors, Notch,
pubmed-meshheading:9665883-Signal Transduction,
pubmed-meshheading:9665883-Transcription Factors,
pubmed-meshheading:9665883-Wing,
pubmed-meshheading:9665883-Wnt1 Protein
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pubmed:year |
1998
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pubmed:articleTitle |
Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein Nubbin.
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pubmed:affiliation |
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
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pubmed:publicationType |
Journal Article
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