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rdf:type |
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lifeskim:mentions |
umls-concept:C0016057,
umls-concept:C0024299,
umls-concept:C0035015,
umls-concept:C0039215,
umls-concept:C0080202,
umls-concept:C0085358,
umls-concept:C0599772,
umls-concept:C1167395,
umls-concept:C1332717,
umls-concept:C1337112,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1527362,
umls-concept:C1548437,
umls-concept:C1706438,
umls-concept:C1882923,
umls-concept:C2603343,
umls-concept:C2698600
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|
pubmed:issue |
2-3
|
|
pubmed:dateCreated |
1998-9-28
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|
pubmed:abstractText |
Rejections of the retrovirus induced lymphomas (ALC and RBL-5) and the methylcholanthrene (MCA) induced fibrosarcoma (MC57X) grafts were tested in syngeneic CD8 and CD4 single and double knockout C57BL/6 mice. The results with the lymphomas showed that the CD8+ T cell deficiency prevented the development of rejection response induced by immunization. Deficiency of the CD4+ T subset abrogated also the rejection of ALC. Immunity against the fibrosarcoma cells developed in both type of single knockout mice, but not in the ones which lacked both CD4+ and CD8+ T cells. Thus CD8+ T cells were required for rejection of the lymphoma cells, while the CD4+ T cells only mediated a weak response. In absence of CD8+ T cells, CD4+ T cells were sufficient to reject the fibrosarcoma cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0165-2478
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9657273-Animals,
pubmed-meshheading:9657273-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9657273-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9657273-Carcinogens,
pubmed-meshheading:9657273-Cell Transplantation,
pubmed-meshheading:9657273-Female,
pubmed-meshheading:9657273-Fibrosarcoma,
pubmed-meshheading:9657273-Graft Rejection,
pubmed-meshheading:9657273-Lymphoma, T-Cell,
pubmed-meshheading:9657273-Male,
pubmed-meshheading:9657273-Methylcholanthrene,
pubmed-meshheading:9657273-Mice,
pubmed-meshheading:9657273-Mice, Inbred C57BL,
pubmed-meshheading:9657273-Mice, Knockout,
pubmed-meshheading:9657273-Rauscher Virus
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|
pubmed:year |
1998
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pubmed:articleTitle |
Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockout hosts.
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pubmed:affiliation |
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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