Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1998-8-19
|
| pubmed:abstractText |
This study is a comparison of the microbiological and clinical efficacy of single-dose fosfomycin trometamol therapy and a 5 day course of trimethoprim in the treatment of uncomplicated urinary tract infection in female patients. Urine dip-slide samples were obtained from 547 female patients aged 18-65 by 22 General Practitioners (GPs) participating in the study from 21 centres in the UK. All patients were diagnosed as having a urinary tract infection by their GP on the basis of history and clinical examination. Patients were randomised to receive either single dose fosfomycin trometamol or a 5 day course of trimethoprim in a 2:1 ratio. Patients who had significant bacteriuria (> or = 10(5) c.f.u/ml) at the first visit (300) were included in the microbiological analysis. The two commonest urinary pathogens isolated were Escherichia coli and Staphylococcus saprophyticus. Trimethoprim resistance was more frequent amongst E. coli isolates whereas fosfomycin trometamol resistance was more common amongst S. saprophyticus isolates. Microbiological cure was demonstrated in 83.3% of the trimethoprim treated group and 83% of the fosfomycin trometamol treated group. Persistence of the infecting bacteria was seen in 17% of each treatment arm.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0924-8579
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
39-47
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9624542-Adult,
pubmed-meshheading:9624542-Aged,
pubmed-meshheading:9624542-Anti-Bacterial Agents,
pubmed-meshheading:9624542-Anti-Infective Agents, Urinary,
pubmed-meshheading:9624542-Citrobacter,
pubmed-meshheading:9624542-Drug Administration Schedule,
pubmed-meshheading:9624542-Enterococcus faecalis,
pubmed-meshheading:9624542-Escherichia coli,
pubmed-meshheading:9624542-Escherichia coli Infections,
pubmed-meshheading:9624542-Family Practice,
pubmed-meshheading:9624542-Female,
pubmed-meshheading:9624542-Fosfomycin,
pubmed-meshheading:9624542-Great Britain,
pubmed-meshheading:9624542-Humans,
pubmed-meshheading:9624542-Klebsiella,
pubmed-meshheading:9624542-Microbial Sensitivity Tests,
pubmed-meshheading:9624542-Middle Aged,
pubmed-meshheading:9624542-Proteus mirabilis,
pubmed-meshheading:9624542-Staphylococcal Infections,
pubmed-meshheading:9624542-Staphylococcus,
pubmed-meshheading:9624542-Trimethoprim,
pubmed-meshheading:9624542-Urinary Tract Infections
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
A comparison between single-dose fosfomycin trometamol (Monuril) and a 5-day course of trimethoprim in the treatment of uncomplicated lower urinary tract infection in women.
|
| pubmed:affiliation |
Department of Medical Microbiology, London Hospital Medical College, UK.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|