9558181

Source:http://linkedlifedata.com/resource/pubmed/id/9558181

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021755, umls-concept:C0039099, umls-concept:C0057678, umls-concept:C0073177, umls-concept:C0086418, umls-concept:C0225369, umls-concept:C1280500, umls-concept:C1456820, umls-concept:C1533691
pubmed:issue	4
pubmed:dateCreated	1998-6-10
pubmed:abstractText	To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) synthesis and expression in human OA synovial membrane, and on the IL-1beta and TNF-alpha receptors on human OA chondrocytes.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7501984
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anthraquinones, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha, http://linkedlifedata.com/resource/pubmed/chemical/diacetylrhein, http://linkedlifedata.com/resource/pubmed/chemical/rhein
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0315-162X
pubmed:author	pubmed-author:CloutierJ MJM, pubmed-author:JolicoeurF CFC, pubmed-author:Martel-PelletierJJ, pubmed-author:MineauFF, pubmed-author:PelletierJ PJP
pubmed:issnType	Print
pubmed:volume	25
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	753-62
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:9558181-Aged, pubmed-meshheading:9558181-Anthraquinones, pubmed-meshheading:9558181-Blotting, Northern, pubmed-meshheading:9558181-Cells, Cultured, pubmed-meshheading:9558181-Chondrocytes, pubmed-meshheading:9558181-Culture Techniques, pubmed-meshheading:9558181-Enzyme Inhibitors, pubmed-meshheading:9558181-Female, pubmed-meshheading:9558181-Humans, pubmed-meshheading:9558181-Interleukin-1, pubmed-meshheading:9558181-Lipopolysaccharides, pubmed-meshheading:9558181-Male, pubmed-meshheading:9558181-Matrix Metalloproteinase 3, pubmed-meshheading:9558181-Middle Aged, pubmed-meshheading:9558181-Osteoarthritis, pubmed-meshheading:9558181-Receptors, Interleukin-1, pubmed-meshheading:9558181-Receptors, Tumor Necrosis Factor, pubmed-meshheading:9558181-Synovial Membrane, pubmed-meshheading:9558181-Tumor Necrosis Factor-alpha
pubmed:year	1998
pubmed:articleTitle	In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes.
pubmed:affiliation	Unité de recherche en arthrose, Centre de recherche L.C. Simard, Campus Notre-Dame, Centre hospitalier universitaire de Montréal, Québec, Canada.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't