Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-5-1
|
| pubmed:abstractText |
Plasminogen activator inhibitor-1 (PAI-1) plasma levels have been consistently related to a polymorphism (4G/5G) of the PAI-1 gene. The renin-angiotensin pathway plays a role in the regulation of PAI-1 plasma levels. An insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been related to plasma and cellular ACE levels. In 1032 employees (446 men and 586 women; 22 to 66 years old) of a hospital in southern Italy, we investigated the association between PAI-1 4G/5G and the ACE I/D gene variants and plasma PAI-1 antigen levels. None of the individuals enrolled had clinical evidence of atherosclerosis. In univariate analysis, PAI-1 levels were significantly higher in men (P<.001), alcohol drinkers (P<.001), smokers (P=.009), and homozygotes for the PAI-1 gene deletion allele (4G/4G) (P=.012). Multivariate analysis documented the independent effect on PAI-1 plasma levels of body mass index (P<.001), triglycerides (P<.001), sex (P<.001), PAI-1 4G/5G polymorphism (P=.019), smoking habit (P=.041), and ACE I/D genotype (P=.042). Thus, in addition to the markers of insulin resistance and smoking habit, gene variants of PAI-1 and ACE account for a significant portion of the between-individual variability of circulating PAI-1 antigen concentrations in a general population without clinical evidence of atherosclerosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1079-5642
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
562-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9555861-Adult,
pubmed-meshheading:9555861-Aged,
pubmed-meshheading:9555861-Aging,
pubmed-meshheading:9555861-Alcohol Drinking,
pubmed-meshheading:9555861-Body Mass Index,
pubmed-meshheading:9555861-Cholesterol,
pubmed-meshheading:9555861-Female,
pubmed-meshheading:9555861-Gene Deletion,
pubmed-meshheading:9555861-Gene Frequency,
pubmed-meshheading:9555861-Genotype,
pubmed-meshheading:9555861-Humans,
pubmed-meshheading:9555861-Hypertension,
pubmed-meshheading:9555861-Male,
pubmed-meshheading:9555861-Middle Aged,
pubmed-meshheading:9555861-Peptidyl-Dipeptidase A,
pubmed-meshheading:9555861-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:9555861-Polymorphism, Genetic,
pubmed-meshheading:9555861-Sex Characteristics,
pubmed-meshheading:9555861-Smoking,
pubmed-meshheading:9555861-Triglycerides
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants.
|
| pubmed:affiliation |
Unita' di Trombosi e Aterosclerosi, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy.
|
| pubmed:publicationType |
Journal Article
|