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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-4-3
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pubmed:abstractText |
Both indirect-response models and effect-compartment models are used to describe the pharmacodynamics of drugs when there is a delay in the time course of the pharmacological effect in relation to the concentration of the drug. The aim of this study was to investigate whether the time of maximum response after single-dose administration at different dose levels could be used to distinguish between these models and to select the most appropriate pharmacokinetic-pharmacodynamic model for frusemide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-3258197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-3330836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-3424416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-7032803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-7379446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-7648775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-7955796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-7955802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-8133465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-8576839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-8576844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9489596-8689815
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9489596-Adult,
pubmed-meshheading:9489596-Cross-Over Studies,
pubmed-meshheading:9489596-Diuretics,
pubmed-meshheading:9489596-Dose-Response Relationship, Drug,
pubmed-meshheading:9489596-Furosemide,
pubmed-meshheading:9489596-Humans,
pubmed-meshheading:9489596-Injections, Intravenous,
pubmed-meshheading:9489596-Male,
pubmed-meshheading:9489596-Models, Biological
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pubmed:year |
1998
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pubmed:articleTitle |
The time of maximum effect for model selection in pharmacokinetic-pharmacodynamic analysis applied to frusemide.
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pubmed:affiliation |
Department of Medical Laboratory Sciences & Technology, Karolinska Institute, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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