rdf:type |
|
lifeskim:mentions |
umls-concept:C0013138,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0039597,
umls-concept:C0080347,
umls-concept:C0185117,
umls-concept:C0205250,
umls-concept:C0205314,
umls-concept:C0591833,
umls-concept:C0679622,
umls-concept:C1334043,
umls-concept:C1623788,
umls-concept:C1704222,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
1998-2-27
|
pubmed:abstractText |
We have cloned two isoforms of cDNAs encoding novel zinc finger proteins. One form encodes a 274-amino acid protein containing an acidic amino acid and serine-rich domain and a zinc finger domain which shows high sequence homology to that of Drosophila Ovo protein. The other form encodes a 179-amino acid protein containing only the zinc finger domain. Expression of both proteins possessing an antigenic epitope in COS cells revealed that they are localized in the nucleus. The 1.3-kbp mRNAs are predominantly expressed in testis, and the expression increases from 3 weeks postnatal, implying that these proteins may play important roles in the development of the testes.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
16
|
pubmed:volume |
421
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
224-8
|
pubmed:dateRevised |
2004-11-18
|
pubmed:meshHeading |
pubmed-meshheading:9468311-Amino Acid Sequence,
pubmed-meshheading:9468311-Animals,
pubmed-meshheading:9468311-Base Sequence,
pubmed-meshheading:9468311-Blotting, Northern,
pubmed-meshheading:9468311-COS Cells,
pubmed-meshheading:9468311-DNA, Complementary,
pubmed-meshheading:9468311-DNA-Binding Proteins,
pubmed-meshheading:9468311-Drosophila,
pubmed-meshheading:9468311-Drosophila Proteins,
pubmed-meshheading:9468311-Gene Expression Regulation, Developmental,
pubmed-meshheading:9468311-Male,
pubmed-meshheading:9468311-Mice,
pubmed-meshheading:9468311-Molecular Sequence Data,
pubmed-meshheading:9468311-Sequence Homology, Amino Acid,
pubmed-meshheading:9468311-Testis,
pubmed-meshheading:9468311-Transcription Factors,
pubmed-meshheading:9468311-Zinc Fingers
|
pubmed:year |
1998
|
pubmed:articleTitle |
Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis.
|
pubmed:affiliation |
Department of Medical Chemistry, Kansai Medical University, Moriguchi, Osaka, Japan.
|
pubmed:publicationType |
Journal Article
|