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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1998-3-12
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pubmed:abstractText |
We examined the effect of intravenous enalaprilat on the course of PAI-1 plasma levels in 23 patients with acute myocardial infarction undergoing thrombolytic therapy. All patients received 100 mg aspirin, 1000 IU/h heparin, thrombolysis with 100 mg rt-PA within 90 min, and betablockers. Eleven out of 23 patients received 5 mg enalaprilat intravenously prior to thrombolysis. Blood samples for determination of PAI-1 plasma levels were collected on admission, 2, 4, 6, 12, and 24 h after thrombolysis. PAI-1 plasma levels in patients receiving enalaprilat were similar to those of the control patients before thrombolysis (5 ng/ml, 95% confidence interval: 2-10 vs. 7 ng/ml, 95% confidence interval: 2-10; p = 0.5). The PAI-1AUC was 9 ng/ml/h (95% confidence interval: 5-10) in the enalaprilat group and 19 ng/ml/h (95% confidence interval: 13-26) in the control group (p = 0.0006). The maximum difference was observed 6 h after thrombolysis (enalaprilat: 13 ng/ml, 95% confidence interval: 5-25, control: 42 ng/ml, 95% confidence interval: 18-55; p = 0.003). Our study clearly demonstrates that application of intravenous enalaprilat prior to thrombolysis attenuates the thrombolysis-related increase of PAI-1. This finding may suggest a possible therapeutic approach to influence the fibrinolytic system in patients with acute myocardial infarction after thrombolysis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-6245
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
140-3
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:9459339-Adult,
pubmed-meshheading:9459339-Aged,
pubmed-meshheading:9459339-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:9459339-Drug Therapy, Combination,
pubmed-meshheading:9459339-Enalaprilat,
pubmed-meshheading:9459339-Female,
pubmed-meshheading:9459339-Humans,
pubmed-meshheading:9459339-Injections, Intravenous,
pubmed-meshheading:9459339-Male,
pubmed-meshheading:9459339-Middle Aged,
pubmed-meshheading:9459339-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:9459339-Prospective Studies,
pubmed-meshheading:9459339-Thrombolytic Therapy,
pubmed-meshheading:9459339-Treatment Outcome
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pubmed:year |
1998
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pubmed:articleTitle |
Attenuation of thrombolysis-induced increase of plasminogen activator inhibitor-1 by intravenous enalaprilat.
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pubmed:affiliation |
Department of Emergency Medicine, University of Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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