Linked Life Data

941811

Source:http://linkedlifedata.com/resource/pubmed/id/941811

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1976-9-25
pubmed:abstractText
Pig cartilage devoid of marrow or synovium is virtually unaffected by rabbit complement-sufficient antiserum to pig erythrocytes (AS + C'), probably because normal cartilage matrix excludes immunoglobulins. When synovium or invading marrow is present, AS + C' causes depletion of the proteoglycan, with consequent entry of IgG into the cartilage, followed by the breakdown of collagen; the chondrocytes assume a fibroblastic form and their reaction with the antiserum is greatly reduced. If degradation of the matrix has not advanced too far, new matrix is regenerated when the explant is transferred to control medium. Experiments on the depletion of pure cartilage by exposure to retinol, indicate that articular cartilage produces enzymes capable of degrading protoglycan but not collagen. The work was done in collaboration with colleagues at the Strangeways Laboratory and in the Division of Immunology, Pathology Department, University of Cambridge.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0065-4299
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
86-90
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
The effect of complement-sufficient antiserum against pig erythrocytes on pig articular tissues in organ culture.
pubmed:publicationType
Journal Article