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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5346
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pubmed:dateCreated |
1998-1-15
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pubmed:abstractText |
The threonine-glycine (Thr-Gly) encoding repeat within the clock gene period of Drosophila melanogaster is polymorphic in length. The two major variants (Thr-Gly)17 and (Thr-Gly)20 are distributed as a highly significant latitudinal cline in Europe and North Africa. Thr-Gly length variation from both wild-caught and transgenic individuals is related to the flies' ability to maintain a circadian period at different temperatures. This phenomenon provides a selective explanation for the geographical distribution of Thr-Gly lengths and gives a rare glimpse of the interplay between molecular polymorphism, behavior, population biology, and natural selection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
278
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2117-20
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9405346-Alleles,
pubmed-meshheading:9405346-Amino Acid Sequence,
pubmed-meshheading:9405346-Animals,
pubmed-meshheading:9405346-Circadian Rhythm,
pubmed-meshheading:9405346-Dipeptides,
pubmed-meshheading:9405346-Drosophila Proteins,
pubmed-meshheading:9405346-Drosophila melanogaster,
pubmed-meshheading:9405346-Genes, Insect,
pubmed-meshheading:9405346-Genetic Variation,
pubmed-meshheading:9405346-Glycine,
pubmed-meshheading:9405346-Haplotypes,
pubmed-meshheading:9405346-Male,
pubmed-meshheading:9405346-Molecular Sequence Data,
pubmed-meshheading:9405346-Nuclear Proteins,
pubmed-meshheading:9405346-Period Circadian Proteins,
pubmed-meshheading:9405346-Phenotype,
pubmed-meshheading:9405346-Polymorphism, Genetic,
pubmed-meshheading:9405346-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:9405346-Sequence Deletion,
pubmed-meshheading:9405346-Temperature,
pubmed-meshheading:9405346-Threonine,
pubmed-meshheading:9405346-Transgenes
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pubmed:year |
1997
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pubmed:articleTitle |
Natural variation in a Drosophila clock gene and temperature compensation.
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pubmed:affiliation |
Department of Genetics, University of Leicester, LE1 7RH, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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