Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
1997-12-11
pubmed:abstractText
Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb). In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini. Embryos lacking maternal gro activity display ectopic tll and hkb transcription; the former leads, in turn, to lack of abdominal expression of the Krüppel and knirps gap genes. We show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repression. Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0950-1991
pubmed:author
pubmed:issnType
Print
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3827-34
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9367438-Abdomen, pubmed-meshheading:9367438-Animals, pubmed-meshheading:9367438-Basic Helix-Loop-Helix Transcription Factors, pubmed-meshheading:9367438-Body Patterning, pubmed-meshheading:9367438-Crosses, Genetic, pubmed-meshheading:9367438-DNA-Binding Proteins, pubmed-meshheading:9367438-Drosophila, pubmed-meshheading:9367438-Drosophila Proteins, pubmed-meshheading:9367438-Embryo, Nonmammalian, pubmed-meshheading:9367438-Female, pubmed-meshheading:9367438-Gene Expression Regulation, Developmental, pubmed-meshheading:9367438-Genes, Insect, pubmed-meshheading:9367438-Insect Hormones, pubmed-meshheading:9367438-Male, pubmed-meshheading:9367438-Mutagenesis, pubmed-meshheading:9367438-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:9367438-Repressor Proteins, pubmed-meshheading:9367438-Signal Transduction, pubmed-meshheading:9367438-Zinc Fingers, pubmed-meshheading:9367438-Zygote
pubmed:year
1997
pubmed:articleTitle
Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression.
pubmed:affiliation
Imperial Cancer Research Fund, London, UK. zparoush@cc.huji.ac.il
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't