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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1997-10-20
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pubmed:abstractText |
Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen receptor (BCR) marks checkpoints in early B cell development that the cells have to pass to survive. To investigate whether the persistence of mature B cells in the peripheral immune system also depends on BCR expression, we have generated a transgenic mouse in which the BCR can be inducibly ablated through V region gene deletion. Ablation leads to rapid death of mature B lymphocytes, which is preceded by down-regulation of MHC antigens and up-regulation of CD95 (Fas) and can be delayed by constitutive bcl-2 expression.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Bcr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcr,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9323135-Animals,
pubmed-meshheading:9323135-Antigens, Surface,
pubmed-meshheading:9323135-Apoptosis,
pubmed-meshheading:9323135-B-Lymphocytes,
pubmed-meshheading:9323135-Cell Differentiation,
pubmed-meshheading:9323135-Female,
pubmed-meshheading:9323135-Flow Cytometry,
pubmed-meshheading:9323135-Gene Deletion,
pubmed-meshheading:9323135-Gene Expression Regulation, Developmental,
pubmed-meshheading:9323135-Gene Targeting,
pubmed-meshheading:9323135-Hematopoietic Stem Cells,
pubmed-meshheading:9323135-Immunoglobulin Heavy Chains,
pubmed-meshheading:9323135-Integrases,
pubmed-meshheading:9323135-Male,
pubmed-meshheading:9323135-Mice,
pubmed-meshheading:9323135-Mice, Transgenic,
pubmed-meshheading:9323135-Oncogene Proteins,
pubmed-meshheading:9323135-Phenotype,
pubmed-meshheading:9323135-Protein-Tyrosine Kinases,
pubmed-meshheading:9323135-Proto-Oncogene Proteins,
pubmed-meshheading:9323135-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9323135-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:9323135-Transfection,
pubmed-meshheading:9323135-Viral Proteins
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pubmed:year |
1997
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pubmed:articleTitle |
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.
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pubmed:affiliation |
Institute for Genetics, University of Cologne, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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