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pubmed-article:9309225pubmed:abstractTextThe central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell cytoplasm. RNA-dependent RNA polymerases comprise a distinct category of polymerases that have limited sequence similarity to reverse transcriptases (RNA-dependent DNA polymerases) and perhaps also to DNA-dependent polymerases. Previously reported structures of RNA-dependent DNA polymerases, DNA-dependent DNA polymerases and a DNA-dependent RNA polymerase show that structural and evolutionary relationships exist between the different polymerase categories.lld:pubmed
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pubmed-article:9309225pubmed:articleTitleStructure of the RNA-dependent RNA polymerase of poliovirus.lld:pubmed
pubmed-article:9309225pubmed:affiliationDepartment of Chemistry and Biochemistry, University of Colorado, Boulder 80309, USA.lld:pubmed
pubmed-article:9309225pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9309225pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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