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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1997-9-30
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pubmed:databankReference | |
pubmed:abstractText |
The mammalian RACK1 protein binds activated protein kinase C, acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. Genes encoding RACK1-like proteins have been isolated from a wide range of eucaryotic organisms; we report the isolation of a Drosophila member of this family. This Drosophila RACK1-like protein shows 76% identity to the mammalian RACK1 proteins, but only about 60% identity to related proteins from plants and fungi. The Drosophila rack1 gene has a dynamic pattern of expression during early embryogenesis with the highest expression in the mesodermal and endodermal lineages.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
1358
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9296523-Amino Acid Sequence,
pubmed-meshheading:9296523-Animals,
pubmed-meshheading:9296523-Base Sequence,
pubmed-meshheading:9296523-Cloning, Molecular,
pubmed-meshheading:9296523-Drosophila,
pubmed-meshheading:9296523-Genes, Insect,
pubmed-meshheading:9296523-Molecular Sequence Data,
pubmed-meshheading:9296523-Peptides,
pubmed-meshheading:9296523-Protein Kinase C,
pubmed-meshheading:9296523-Sequence Homology, Amino Acid,
pubmed-meshheading:9296523-Signal Transduction
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pubmed:year |
1997
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pubmed:articleTitle |
Isolation and cloning of a Drosophila homolog to the mammalian RACK1 gene, implicated in PKC-mediated signalling.
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pubmed:affiliation |
Department of Biological Sciences, Barnard College, New York, NY 10027, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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