| pubmed-article:9246206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0023277 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:9246206 | lifeskim:mentions | umls-concept:C0206741 | lld:lifeskim |
| pubmed-article:9246206 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9246206 | pubmed:dateCreated | 1997-8-21 | lld:pubmed |
| pubmed-article:9246206 | pubmed:abstractText | Resistance to the Leishmaniae is associated with interferon (IFN)-gamma mediated activation of macrophages. In this study, Balb/c mice were infected with three Leishmania strains that cause progressively growing cutaneous lesions without obvious dissemination: L. mexicana mexicana giving rise to rapidly growing lesions, and L. (Viannia) panamensis and L. mexicana-like, which both cause slowly developing lesions. The rate of lesion growth was compared to induction of early local and systemic IFN-gamma responses. All the three parasite strains induced increased levels of IFN-gamma transcripts 24 h after infection. Infection with the more aggressive strain resulted in a notably lower IFN-gamma response when compared to infection with the two low pathogenic strains. Interleukin-4 (IL-4) mRNA appeared 7 days after infection with L. (Viannia) panamensis and L. mexicana-like but not with L. mexicana mexicana. Thus, virulence of these Leishmania strains could not be associated with induction of IL-4 during the first week after infection. In addition, none of the Leishmania strains induced detectable mRNA for IL-12 or inducible nitric oxide synthase (iNOS). These data present a picture somewhat different from that which has been described in L. major experimental infection. | lld:pubmed |
| pubmed-article:9246206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9246206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9246206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9246206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9246206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9246206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9246206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9246206 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9246206 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:9246206 | pubmed:author | pubmed-author:OrrEE | lld:pubmed |
| pubmed-article:9246206 | pubmed:author | pubmed-author:UnoYY | lld:pubmed |
| pubmed-article:9246206 | pubmed:author | pubmed-author:Guevara-Mendo... | lld:pubmed |
| pubmed-article:9246206 | pubmed:author | pubmed-author:Franceschi... | lld:pubmed |
| pubmed-article:9246206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9246206 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:9246206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9246206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9246206 | pubmed:pagination | 35-40 | lld:pubmed |
| pubmed-article:9246206 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:meshHeading | pubmed-meshheading:9246206-... | lld:pubmed |
| pubmed-article:9246206 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9246206 | pubmed:articleTitle | Experimental infection of Balb/c mice with Leishmania panamensis and Leishmania mexicana: induction of early IFN-gamma but not IL-4 is associated with the development of cutaneous lesions. | lld:pubmed |
| pubmed-article:9246206 | pubmed:affiliation | Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:9246206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9246206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9246206 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9246206 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9246206 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9246206 | lld:pubmed |
