Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1997-8-12
|
| pubmed:abstractText |
Various studies have reported the utility of anti-CD34 staining in the differential diagnosis of dermal spindle-cell tumors. To investigate whether monoclonal antibody Ki-M1p might add practical diagnostic information, we examined a total of 120 cutaneous spindle cell neoplasms using a panel of markers. Anti-CD34 antibody QBEnd/10 consistently stained dermatofibrosarcomas, Kaposi's sarcomas, neurofibromas, and, to a lesser extent, hemangiopericytomas. A positive reaction was also found in > 18% of the dermatofibromas. Ki-M1p staining showed an intense immunoreaction in all dermatofibromas, whereas no reactivity was observed in dermatofibrosarcomas. In addition, a subset of cells was labeled in atypical fibroxanthomas and Kaposi's sarcomas. Neurofibromas, spindle-cell hemangioendotheliomas, and hemangiopericytomas were negative. Dermatofibrosarcomas and atypical fibroxanthomas also moderately expressed smooth muscle-specific actin. Immunohistochemically, a discrimination between dermatofibrosarcomas and neurofibromas was possible only by means of an antibody against the nerve growth factor receptor. We conclude that the combination of several antibodies, in particular anti-CD34 and Ki-M1p, may improve the accuracy of diagnostic immunohistochemistry in the field of cutaneous spindle cell tumors. We speculate that dermatofibroma is primarily a macrophage-rich inflammatory lesion in which cytokine secretion induces a secondary proliferation of fibroblasts, whereas dermatofibrosarcoma is likely to issue from primitive dermal cells of uncertain origin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Ki antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteasome Endopeptidase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0147-5185
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
791-800
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9236835-Antibodies, Monoclonal,
pubmed-meshheading:9236835-Antigens, CD34,
pubmed-meshheading:9236835-Antigens, Surface,
pubmed-meshheading:9236835-Autoantigens,
pubmed-meshheading:9236835-Cytoplasm,
pubmed-meshheading:9236835-Dermatofibrosarcoma,
pubmed-meshheading:9236835-Diagnosis, Differential,
pubmed-meshheading:9236835-Endothelium, Vascular,
pubmed-meshheading:9236835-Hemangiopericytoma,
pubmed-meshheading:9236835-Humans,
pubmed-meshheading:9236835-Immunophenotyping,
pubmed-meshheading:9236835-Neurofibroma,
pubmed-meshheading:9236835-Nuclear Proteins,
pubmed-meshheading:9236835-Proteasome Endopeptidase Complex,
pubmed-meshheading:9236835-Sarcoma, Kaposi,
pubmed-meshheading:9236835-Sensitivity and Specificity,
pubmed-meshheading:9236835-Skin Neoplasms,
pubmed-meshheading:9236835-Tumor Markers, Biological
|
| pubmed:year |
1997
|
| pubmed:articleTitle |
Immunophenotyping of dermal spindle cell tumors: diagnostic value of monocyte marker Ki-M1p and histogenetic considerations.
|
| pubmed:affiliation |
Department of General Pathology, University of Kiel, Germany.
|
| pubmed:publicationType |
Journal Article
|