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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0012171,
umls-concept:C0015502,
umls-concept:C0016006,
umls-concept:C0030190,
umls-concept:C0271650,
umls-concept:C0392747,
umls-concept:C0441655,
umls-concept:C0681850,
umls-concept:C1280500,
umls-concept:C1550501,
umls-concept:C1554963,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
6
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pubmed:dateCreated |
1997-7-7
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pubmed:abstractText |
Our aim was to assess the impact of a monounsaturated fat-enriched (Mono) diet and a diet recommended by the National Cholesterol Education Program (NCEP) on plasma levels of fibrinogen and activities of factor VII (FVII:C) and plasminogen activator inhibitor-1 (PAI-1) and the impact of genetic polymorphisms of these variables (HaeIII, MspI, and 4G/5G polymorphisms, respectively) in 28 subjects with impaired glucose tolerance ([IGT] 17 men and 11 women; mean age, 55.6 +/- 5.5 years). A diet rich in fat and saturated fatty acids served as a baseline diet for 3 weeks. Thereafter, subjects were randomized for the next 8 weeks to either the Mono diet (n = 12) or NCEP diet (n = 18). Fibrinogen levels or PAI-1 activities did not change with either of the diets, but fibrinogen levels were higher (3.4 +/- 0.5 v 4.0 +/- 0.6 g/L, P = .007 at baseline) throughout the study in heterozygous subjects with respect to HaeIII polymorphism. This polymorphism and age accounted for 38% of the variation of fibrinogen levels. MspI polymorphism together with body mass index explained 51% of the variation of FVII:C, which was higher in subjects with the M1M1 genotype compared with M1M2/M2M2 genotypes (127% +/- 21% v 90% +/- 12%, P < .001). FVII:C showed a decrease with the NCEP diet (P < .05), but the decline was confined to M1M1 subjects. PAI-1 activity did not differ significantly between the genotypes. The insulin sensitivity index (SI) obtained by the minimal model method was the main explanatory variable of PAI-1 activity. To conclude, despite good compliance, the fat-modified diet did not alter plasma levels of fibrinogen or PAI-1 in white subjects with IGT. FVII:C levels decreased with the NCEP diet, but this was confined to subjects with the M1M1 genotype.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease HpaII,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Factor VII,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinogen,
http://linkedlifedata.com/resource/pubmed/chemical/GGCC-specific type II...,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0026-0495
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
666-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9186303-Analysis of Variance,
pubmed-meshheading:9186303-Deoxyribonuclease HpaII,
pubmed-meshheading:9186303-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:9186303-Dietary Fats,
pubmed-meshheading:9186303-Dietary Fats, Unsaturated,
pubmed-meshheading:9186303-Factor VII,
pubmed-meshheading:9186303-Female,
pubmed-meshheading:9186303-Fibrinogen,
pubmed-meshheading:9186303-Genotype,
pubmed-meshheading:9186303-Glucose Intolerance,
pubmed-meshheading:9186303-Heterozygote,
pubmed-meshheading:9186303-Humans,
pubmed-meshheading:9186303-Male,
pubmed-meshheading:9186303-Middle Aged,
pubmed-meshheading:9186303-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:9186303-Polymorphism, Restriction Fragment Length
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pubmed:year |
1997
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pubmed:articleTitle |
Effects of dietary fat modification on fibrinogen, factor VII, and plasminogen activator inhibitor-1 activity in subjects with impaired glucose tolerance.
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pubmed:affiliation |
Department of Clinical Nutrition, University of Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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