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There is evidence that tumour necrosis factor alpha (TNF alpha) may be an important mediator in initiating asthmatic airway inflammation. It has been proposed that endothelin-1 (ET-1) is involved in bronchoconstriction and airway remodelling in asthma. It is not known, however, if there is any interaction between TNF alpha and ET in perpetuating airway inflammation in asthma.
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